姓名：牛銀杰

職稱：助理研究員

學歷、學位：研究生、博士

聯系電話：17665120530

電子郵件：niuyinjie0530@163.com

個人簡介：

女、博士、中國水產科學研究院"水科英才"青年英才培育對象，現為疫苗創制與疫病區域化控制創新團隊主要成員。作為疫苗創制與疫病區域化控制創新團隊主要成員。圍繞鱖、鱸、鱧等名優魚類主要疾病，長期從事水產病害防治研究。主持省自然科學基金面上項目1項，國家重點研發計劃子任務一項，廣州市科技特派員項目1項，廣州市科技計劃項目1項，所自主創新項目2項，參與支撐計劃（攻關計劃）、公益性農業行業專項等重大項目30余項，發表文章30余篇，其中SCI收錄30篇（第一作者12篇）；獲國家發明專利3項，并進行轉化，參編專著1部。

研究方向：

圍繞兩苗一區，聚焦：

1.鱖鱸鱧病毒病的致病機制研究

2.鱖鱸鱧病毒弱毒疫苗的研制

3.鱖鱸鱧病毒疫苗的規模化懸浮制備

構建“基礎研究-應用研發-產業轉化”全鏈條技術體系

獲獎情況：

鱖鱸鱧病毒病全鏈條精準防控關鍵技術研究與示范，2024年中國水產科學研究院科技進步一等獎，第5完成人

近幾年代表性論文及其他代表性成果：

1.Yinjie Niu, Caimei Ye, Qiang Lin, Hongru Liang, Xia Luo, Baofu Ma, Ningqiu Li, Xiaozhe Fu. Infectious Spleen and Kidney Necrosis Virus ORF093R and ORF102R Regulate Glutamate Metabolic Reprogramming to Support Virus Proliferation by Interacting with c-Myc. Int J Mol Sci. 2025 Jan 16;26(2):718.

2.Yinjie Niu, Xinmei Yang, Hongru Liang, Xia Luo, Baofu Ma , Qiang Lin, Xiaozhe Fu and Ningqiu Li. scTRIM44 Positively Regulated Siniperca Chuatsi Rhabdovirus Through RIG-I- and MDA5-Mediated Interferon Signaling. Viruses 2024, 16,1876.

3.Yinjie Niu, Saiya Ma, Hongru Liang, Xiaozhe Fu, Baofu Ma, Qiang Lin, Xia Luo and Ningqiu Li. The Stability and Efficency of CPB Cells Were Acclimated for Virus Proliferation. Vaccines 2024, 12, 220.

4.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Xia Luo, Shaozhi Zuo, Lihui Liu and Ningqiu Li*. Epidermal growth factor receptor promotes infectiousspleen and kidney necrosis virus invasion via PI3K-Akt signaling pathway. Journal of General Virology 2023;104:001882.

5.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Xia Luo, Shaozhi Zuo, Lihui Liu, Ningqiu Li*. In vivo and in vitro, antiviral effects of two mixture of Chinese herbal drug active monomers against MSRV and LMBV in largemouth bass (Micropterus salmoides). Aquaculture 577 (2023) 739977.

6.Yinjie Niu , Xiaozhe Fu , Qiang Lin , Hongru Liang , Xia Luo , Shaozhi Zuo , Lihui Liu , Ningqiu Li*. The composition and antiviral activity of scTRIM59 in Mandarin fish. Fish and Shellfish Immunology 130 (2022) 86–92.

7.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Lihui Liu, Xia Luo, Hongru Liang, Ningqiu Li*. Gefitinib inhibits infectious spleen and kidney necrosis virus infection in vivo and vitro by blocking virus endocytosis. Aquaculture 539 (2021) 736614.

8.Yinjie Niu, Xiaozhe Fu, Lihui Liu, Qiang Lin, Hongru Liang, Zhibin Huang, Ningqiu Li*. Molecular characterization and function of EGFR during viral infection process in Mandarin fishSiniperca chuatsi. Fish and Shellfish Immunology 102 (2020) 211–217.